谢文林，男，1967年生，博士，教授，硕士生导师。主要从事新型抗肿瘤药物的设计、合成和分子机理研究以及酪氨酸酶、葡萄糖苷酶、乙酰胆碱酯酶等酶抑制剂的设计合成和活性筛选。近年来主持国家自然科学基金面上项目1项、湖南省自然科学基金等省部级项目6项、药物研发横向课题4项。获湖南省自然科学三等奖一项，获省部级教学成果二等奖、三等奖各1项，指导研究生获湖南省第八届研究生创新论坛优秀论文一等奖1项。在Adv. Synth. Catal., J. Org. Chem., Chem.-Asian J., Eur. J. Med. Chem., Bioorg. Med. Chem. Lett., Chem. Biol. Drug Des.,J. pept. Sci.和化学学报等国内外重要刊物上共发表学术论文50余篇，SCI收录30余篇。申请中国发明专利12项，授权5项。

联系方式：Email: xwl2000zsu@163.com

  研究方向：

       1、类天然有机小分子的设计与合成；

       2、药物分子的设计、合成与生物活性研究；

主持的科研或教研项目：

以G-四链体为靶的Isatin衍生物及其金属配合物的合成和抗癌作用（No. 21571058），国家自然科学基金， 70.0万元, 2016,01-2019,12

发表的主要论文：

[1]. Yanfang Yao, Ziqing Yin, Weiyun Chen, Wenlin Xie,* Fu-Sheng He,b,* and Jie Wub*, A Concise Route to 2-Sulfonylacetonitriles from Sodium Metabisulfite, Advanced Synthesis & Catalysis, 2021, 363, 570–574.

[2]. Liangkun Ji, Ying Zhou, Qiuyan Yu, Yaxuan Fang, Yongjun Jiang, Yunhui Zhao, Chuntao Yuan, Wenlin Xie*, Synthesis and anticancer activity of new spirooxindoles incorporating[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine moiety, Journal of Molecular Structure, 2021, 1227, 129406-129412

[3]. Renzhi Liu, Min Yang, Wenlin Xie*, Wenbi Dong, Hongwei Zhou, Sarita Yadav, Vladimir Ivano-vich Potkin, Guanyinsheng Qiu*, Synthesis of 3-Hydroxy- isoindolin- 1-ones Through 1, 4-Dioxane-Mediated Hydroxylhydrative aza-Cycli-zation of 2-Alkynylbenzamide in Water, Journal of Organic Chemistry, 2020, 85, 5312−5320

[4]. Renzhi Liu, Meng Li, Wenlin Xie*, Hongwei Zhou*, Yajing Zhang, Guanyinsheng Qiu*, Tunable Synthesis of 3-Hydroxylisoquinolin-1, 4-dione and Isoquinolin-1-one Enabled by Copper-Catalyzed Radical 6-Endo Aza-Cyclization of 2-Alkynylbenzamide, Journal of Organic Chemistry, 2019, 84, 11763−11773

[5].Wenlin Xie*, Yiqiang Wu, Jingai Zhang, Qihong Mei, Yahan Zhang, Ning Zhu, Renzhi Liu, Huilin Zhang, Design, synthesis and biological evaluations of novel pyridone-thiazole hybrid molecules as antitumor agents, European Journal of Medicinal Chemistry, 2018, 145, 35-40

[6]. Wenlin Xie*, Huilin Zhang, Jingjing He, Jingai Zhang, Qiuyan Yu, Chunxiang Luo, Shangru Li，Synthesis and Biological Evaluation of novel hydroxybenzaldehyde-based analogues as inhibitors of mushroom tyrosinase, Bioorganic & Medicinal Chemistry Letters, 2017,27(3): 530-532

[7]. Wenlin Xie *, Jingai Zhang, Xiaojing Ma, Wenqian Yang, Ying Zhou, Xufu Tang, Yan Zou, Hui Li, Jingjing He, Shimin Xie, Yunhui Zhao, Fengping Liu,Evaluation of Kojic Acid Derivatives Containing 1,2,4-triazole as Potent Tyrosinase Inhibitors, Chemical Biology & Drug Design, 2015, 86(5): 1087–1092

[8]. Wenlin Xie*, Shimin Xie, Ying Zhou, Xufu Tang, Jian Liu, Wenqian Yang, Minghua Qiu, Design and synthesis of novel 5,6-disubstituted pyridine-2,3- dione-3-thiosemicarbazone derivatives as potential anticancer agents, European Journal of Medicinal Chemistry, 2014, 81, 22-27

[9].  Xianyong Yu*, Zhixi Liao, Qing Yao, Heting Liu, Wenlin Xie*, Spectroscopic studies on the interaction of phacolysin and bovine serum albumin, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 127, 231–236

出版教材或专著：

谢文林等主编. 有机化学实验(第二版)，湘潭大学出版社，2018

授权发明专利：

[1]. 谢文林，唐绪福，杨文前，腾珍珍, 一种5-取代-4-[5-羟基-4-吡喃酮-2-基-亚甲氨基]-3-巯基-1,2,4-**类化合物及其用途,专利号：ZL201310235619.6.

[2]. 谢文林，唐绪福, 杨文前, 5-取代-3-[5-羟基-4-吡喃酮-2-基-甲硫基]-4-氨基-1,2,4-**类化合物及其用途, 专利号：ZL201310198771.1.

[3]. 谢文林，张慧霖，余秋艳，吴乙强，梅期宏，骆春香，一种含螺吲哚-2-酮衍生物及其制备方法和作为抗癌药物的应用，专利号：ZL201610309985.5

[4]. 谢文林，张金改，余秋艳，何晶晶，李芯蕊，骆春香，李尚儒，柳建斌，5-取代-3-[5-羟基-4-吡喃酮-2-基-甲硫基]-4-羟基苯甲氨基-1,2,4-**类化合物及其用途，专利号：ZL201510414130.4

[5]. 谢文林，吴乙强，梅期宏，张金改，张慧霖，刘仁志，一种含噻唑环吡啶酮衍生物及其制备方法和应用，专利号：ZL201710435688.X