基本情况

谷慧，女，1988年生，博士，副教授，现任化学化工学院应用化学研究所副所长。主要从事生物电化学分析及其活体分析中的生物活性分子在体研究，近年来主持国家自然科学基金面上项目1项、省部级项目2项。近年来在《Anal. Chem.》、《ACS Appl. Mater. Interfaces》、《Biosens Bioelectron》等SCI上公开发表论文20余篇。

学习经历

2006.09-2010.06，湖南师范大学，学士，制药工程

2010.09-2015.06，华东师范大学，博士，分析化学

2013.09-2014.09，美国匹兹堡大学，联合培养博士，分析化学

2022.09-2024.08，瑞典哥德堡大学，玛丽居里学才，分析化学

工作经历

2015.10-至今，湖南科技大学，教师

承担课程

《分析化学实验》

《药物分析》

《制药工程专业英语》

主持课题

[1] 湖南省教育厅优秀青年项目，基于界面分子组装策略的微传感器研究及其在在体神经递质分析中的应用，优秀青年项目，（No. 20B221），6万，2020.11至今

[2] 湖南省自然科学基金面上项目，基于石墨烯缺陷效应的在体电化学技术研究及其在脑神经科学中的应用，面上项目，（No. 2021JJ30238），5万，2021.01至今

[3] 国家自然科学基金，基于改性3D石墨烯的在体电化学分析方法研究及其在活体分析中的应用（No. 21605047），20万，2017.01-2019.12

[4] 湖南省自然科学基金，改性3D石墨烯复合材料的设计及其在电化学生物传感器中的应用（No. 2017JJ3080），5万，2017.01-2019.12

[5] 湖南省教育厅科学研究一般项目，基于神经递质的在体分析方法及其在阿尔兹海默症机理研究中的应用（No. 17C0627），1万，2017.01-2019.12。

代表性论文

1. Ziyi Zhang; Mengyin Li; Yimei Zuo; Shu Chen*; Yi Zhuo; Ming Lu; Guoyue Shi; Hui Gu*; In Vivo Monitoring of pH in Subacute PD Mouse Brains with a Ratiometric Electrochemical Microsensor Based on Poly(melamine) Films, ACS Sensors 2022, 7(1): 235-244.

https://pubs.acs.org/doi/full/10.1021/acs.analchem.1c03965

2. Zhibei Qu#; Yimin Jiang#; Jiaxin Zhang; Shu Chen; Rongjin Zeng; Yi Zhuo; Ming Lu; Guoyue Shi; Hui Gu*; Tailoring Oxygen-Containing Groups on Graphene for Ratiometric Electrochemical Measurements of Ascorbic Acid in Living Subacute Parkinson’s Disease Mouse Brains, Analytical Chemistry 2021, 93(49): 16598-16607.

https://pubs.rsc.org/en/content/articlelanding/2021/an/d1an01370j

3. Xia Xiao, Chenchen Li, Yuzhi Liu, Yaqian Feng, Kai Han, Haoyue Xiang*, Guoyue Shi, Hui Gu*,A ratiometric electrochemical microsensor for monitoring of chloride ion in vivo, Analyst 2021, 146, 6202-6210.

https://pubs.rsc.org/en/content/articlelanding/2021/an/d1an01370j

4. Chenchen Li#, Yi Zhuo#, Xia Xiao, Shuangfu Li, Kai Han*, Ming Lu, Jiaxin Zhang, Shu Chen, Hui Gu*, Facile electrochemical microbiosensor based on in situ self-assembly of Ag nanoparticles coated on Ti3C2Tx for in vivo measurements of chloride ions in the PD mouse brain, Analytical Chemistry 2021, 93, 21, 7647–7656. (1 citation)

https://pubs.acs.org/doi/10.1021/acs.analchem.1c00342

5. Yimin Jiang#, Xia Xiao#, Chenchen Li, Yu Luo, Shu Chen, Guoyue Shi, Kai Han, Hui Gu*, Facile ratiometric electrochemical sensor for in vivo/online repetitive measurements of cerebral ascorbic acid in brain microdiaysate. Analytical Chemistry 2020, 92, 5: 3981–3989. (12 citations)

https://pubs.acs.org/doi/10.1021/acs.analchem.9b05484

6. Hui Gu*, Yanqiu Guo, Xia Xiao, Chenchen Li, Guoyue Shi, Jian He*, Double molecular recognition strategy based on boronic acid−diol and NHS ester−amine for selective electrochemical detection of cerebral dopamine. Analytical and Bioanalytical Chemistry 2020, 412, 3727–3736. (3 citations)

https://link.springer.com/article/10.1007/s00216-020-02624-6

7. Hui Gu*, Qi Hou, Yu Liu, Yujie Cai, Yanqiu Guo, Haoyue Xiang, Shu Chen*, On-line regeneration of electrochemical biosensor for in vivo repetitive measurements of striatum Cu2+ under global cerebral ischemia/reperfusion events, Biosensensors Bioelectronics 2019, 135: 111–119. (12 citations)

https://www.sciencedirect.com/science/article/abs/pii/S0956566319302076?via%3Dihub

8. Hui Gu*, Yu Liu, Tianyao Ren, Wenbiao Xia, Yanqiu Guo, Guoyue Shi, 2019, 135: 111–119. An ele Biosensensors Bioelectronics 2019, 135: 111–119.ctrochemical biosensor based on double molecular recognition for selective monitoring of cerebral dopamine dynamics at 4 min interval, Sensors Actuators B: Chemcal 2019, 287: 356–363. (11 citations)

https://www.sciencedirect.com/science/article/abs/pii/S0925400519302059?via%3Dihub

9. Hui Gu*, Yidan Xing, Ping Xiong, Huiling Tang, Chenchen Li, Shu Chen, Rongjin Zeng, Kai Han*, Guoyue Shi, Three-dimensional porous Ti3C2Tx MXene–graphene hybrid films for glucose biosensing. ACS Applied Nano Materials 2019, 2: 6537−6545. (27 citations)

https://pubs.acs.org/doi/10.1021/acsanm.9b01465

10. Hui Gu*, Ping Xiong, Huiling Tang, Shu Chen, Yunfei Long, Guoyue Shi, In vivo monitoring of cerebral glucose with an updated on-line electroanalytical system. Analytical and Bioanalytical Chemistry 2019, 411, 5929–5935. (3 citations)

https://link.springer.com/article/10.1007%2Fs00216-019-02002-x

11. Huiling Tang, Dehao Cai, Tianyao Ren, Ping Xiong, Yu Liu, Hui Gu*,Guoyue Shi, Fabrication of a low background signal glucose biosensor with 3D network materials as the electrocatalyst. Analytical Biochemistry 2019, 567, 63–71. (11 citations)

https://www.sciencedirect.com/science/article/abs/pii/S0003269718308005?via%3Dihub

12. Hui Gu*, Huiling Tang, Ping Xiong, Zhihua Zhou*, Biomarkers-based Biosensing and Bioimaging with Graphene for Cancer Diagnosis. Nanomaterials 2019, 9, 130. (24 citations)

https://www.mdpi.com/journal/nanomaterials

13. Hui Gu, Varner Erika L., Groskreutz Stephen R., Michael Adrian C.,Weber Stephen G.*, In vivo monitoring of dopamine by microdialysis with 1 min temporal resolution using online capillary liquid chromatography with electrochemical detection, Analytical Chemistry 2015, 87(12):6088-6094. (65 citations)

https://pubs.acs.org/doi/10.1021/acs.analchem.5b00633

14. Hui Gu, Tianshu Zhou, Guoyue Shi*, Synthesis of graphene supported graphene-like C3N4 metal-free layered nanosheets for enhanced electrochemical performance and their biosensing for biomolecules, Talanta 2015, 132:871-876. (39 citations)

https://www.sciencedirect.com/science/article/abs/pii/S0039914014008200?via%3Dihub

研究方向

活体电分析化学