基本情况

李毅，男，1986年9月出生，博士，副教授，硕士研究生导师。2014年博士毕业于中山大学。湖南科技大学“奋进学者”（青年创新人才）。主要研究方向为过渡金属配合物的抗肿瘤及生物成像研究。近年来，先后共主持国国家自然科学基金，湖南省自然科学基金，中国博士后基金等项目。在Biomaterials、Chemical Science、Chemical Communications、Sensors and Actuators B: Chemical、Dalton Transactions等重要学术期刊上发表论文20余篇，论文被引1000余次。

学习经历

2005年09月—2009年06月 吉首大学，学士

2009年09月—2014年12月 中山大学（硕博连读），博士

工作经历

2015年01月—2017年07月 中山大学中山医学院，博士后

2017年07月—2018年12月 湖南科技大学

2018年12月—至今 湖南科技大学，副教授

承担课程

《无机化学》《普通化学》《无机化学实验》

主持课题

[1] 国家自然科学基金青年基金，21601210，2017.01-2019.12，主持。

[2] 湖南省自然科学基金，2019JJ50188，2019.01-2021.12，主持。

[3] 中国博士后科学基金，2015M572397，2015.01-2016.12，主持。

代表性论文

[1] Ben Liu, Jing Long, Meng Zhang, Kaiming Cheng, Xin Gao, Yibo Zhou, Yi Li *, Zilong Tang*, Wei Zhang*. Mitochondria-targeted phosphorescent cyclometalated iridium(III) complex for bioimaging of H2S. J. Inorg. Biochem., 2022, 226, 111626.

[2] Xiang-Fu Du#, Yi Li # (共同第一作者), Jing Long, Wei Zhang?, Dou Wang, Cai-Rong Li , Mei-Xia Zhao?, Yuxiao Lai,? Fabrication of cisplatin-loaded polydopamine nanoparticles via supramolecular self-assembly for photoacoustic imaging guided chemo-photothermal cancer therapy. Appl. Mater. Today 2021, 23, 101019.

[3] Wei Zhang,# Yi Li# (共同第一作者), Lanju Xu,? Dou Wang, Jing Long, Meng Zhang, Yufei Wang, Yuxiao Lai* and Xing-Jie Liang.* Near-Infrared-Absorbing Conjugated Polymer Nanoparticles Loaded with Doxorubicin for Combinatorial Photothermal- Chemotherapy of Cancer. ACS Appl. Polym. Mater. 2020, 2, 4180?4187.

[4] Yi Li,* Ben Liu, Cui-Xia Xu, Liang He, Yi-Chao Wan, Liang-Nian Ji and Zong-Wan Mao*. Mitochondria-targeted phosphorescent cyclometalated iridium(III) complexes: Synthesis, characterization and anticancer properties. J. Biol. Inorg. Chem., 2020, 25, 597-607.

[5] Yi Li, Kang-Nan Wang, Liang He, Liang-Nian Ji and Zong-Wan Mao*, Synthesis, photophysical and anticancer properties of mitochondria-targeted phosphorescent cyclometalated iridium(III) N-heterocyclic carbene complexes. J. Inorg. Biochem., 2020, 205, 110976.

[6] Yi Li, Kang-Nan Wang, Liang He, Liang-Nian Ji and Zong-Wan Mao*, Synthesis, photophysical and anticancer properties of mitochondria-targeted phosphorescent cyclometalated iridium(III) N-heterocyclic carbene complexes. J. Inorg. Biochem., 2020, 205, 110976.

[7] Yi Li, Kang-Nan Wang, Bing Liu, Xin-Ran Lu, Meng-Feng Li,* Liang-Nian Ji and Zong-Wan Mao*, Mitochondria-targeted two-photon fluorescent probe for the detection of biothiols in living cells. Sensors and Actuators B: Chemical 2018, 255, 193-202.

[8] Yi Li, Kang-Nan Wang, Bing Liu, Xin-Ran Lu, Meng-Feng Li,* Liang-Nian Ji and Zong-Wan Mao*, Cyclometalated iridium(III) N-heterocyclic carbene complexes as potential mitochondrial anticancer and photodynamic agents. Dalton Trans ., 2017, 46, 11363-11371.

[9] Yi Li, Cai-Ping Tan, Wei Zhang, Liang He, Liang-Nian Ji and Zong-Wan Mao*, Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents. Biomaterials 2015, 39, 95-104.

[10] Yi Li, Gao-Feng Liu,* Cai-Ping Tan, Liang-Nian Ji and Zong-Wan Mao*, Antitumor properties and mechanisms of mitochondria-targeted Ag(I) and Au(I) complexes containing N-heterocyclic carbenes derived from cyclophanes. Metallomics 2014, 6, 1460-1468.

[11] Liang He, Yi Li, Cai-Ping Tan,* Rui-Rong Ye, Mu-He Chen, Jian-Jun Cao, Liang-Nian Ji and Zong-Wan Mao*, Cyclometalated iridium(III) complexes as lysosome targeted photodynamic anticancer and real-time tracking agents. Chem. Sci. , 2015, 6, 5409-5418.

[12] Qian Cao, Yi Li, Eva Freisinger, Peter Z. Qin,* Roland K. O. Sigel,* and Zong-Wan Mao*, G-Quadruplex DNA Targeted Metal Complexes Acting as Potential Anticancer Drugs. Inorg. Chem. Front., 2017, 4, 10-32.

[13] Wei Zhang, Yi Li, Jing-Hua Sun, Cai-Ping Tan, Liang-Nian Ji and Zong-Wan Mao*, Supramolecular self-assembled nanoparticles for chemo-photodynamic dual therapy against cisplatin resistant cancer cells. Chem. Commun. , 2015, 51, 1807-1810.

[14] Jin-Tao Wang, Yi Li, Jia-Heng Tan, Liang-Nian Jia and Zong-Wan Mao*, Platinum(II)-triarylpyridines complexes with electropositive pendants as efficient G-quadruplex binders. Dalton Trans ., 2011, 40, 564-566.